This document describes a systematic approach to assess potential occupational risks related to nano-objects and their agglomerates and aggregates (NOAA) arising from the production and use of nanomaterials and/or nano-enabled products. This approach provides guidance to identify exposure routes, exposed body parts and potential consequences of exposure with respect to skin uptake, local effects and inadvertent ingestion. This document also considers occupational use of products containing NOAA by professionals, e.g. beauticians applying personal care products, cosmetics or pharmaceuticals, but does not apply to deliberate or prescribed exposure to these products by consumers. This document is aimed at occupational hygienists, researchers and other safety professionals to assist recognition of potential dermal exposure and its potential consequences.