Nanotechnologies - Characterization of nanoparticles in inhalation exposure chambers for inhalation toxicity testing

Nanotechnologies - Characterization of nanoparticles in inhalation exposure chambers for inhalation toxicity testing

Standard Number DIN EN ISO 10808
Organization German institute for standardization Germany
Level National
Category Specification
Status
  • APR 2011 Published
ABSTRACT
This International Standard specifies requirements for, and gives guidance on, the characterization of airborne nanoparticles in inhalation exposure chambers for the purpose of inhalation toxicity studies in terms of particle mass, size distribution, number concentration and composition. This International Standard proposes a number of monitoring functions for the inhalation toxicity testing chamber, including a differential mobility analyzing system (DMAS) for measuring particle number, size, distribution, surface area and estimated mass dose, as well as morphological examination using transmission electron microscopy (TEM) or scanning electron microscopy (SEM) equipped with an energy dispersive X-ray analyzer (TEM-EDXA) for chemical composition. This International Standard also takes into account conventional mass dose monitoring and other physicochemical monitoring, for use when deemed a necessary parameter for toxicity determination. The method evaluates nano-sized particle surface area, mass dose, particle distribution, composition and dispersion to support effective analysis of inhalation toxicity testing results.