Research & Science NEWS

Engineered E. Coli Delivers Therapeutic Nanobodies to the Gut

2023-04-09

Engineered E. Coli Delivers Therapeutic Nanobodies to the Gut

Researchers have succeeded in developing an E. coli-based “smart microbe” that secretes therapeutic payloads, including antibodies, into the gut. In mouse models, the smart microbe was as efficacious as a systemically delivered conventional monoclonal antibody in limiting colitis in inflammatory bowel disease. This smart microbe has the potential to treat a variety of diseases, including...