Nanoparticle-delivered RNA reduces neuroinflammation in lab tests
Date | 11th, Dec 2023 |
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Source | Phys.org - Scientific News Websites |
DESCRIPTION
Some COVID-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a potential Alzheimer's disease (AD) therapy. In tests in multiple mouse models and with cultured human cells, a newly tailored LNP formulation effectively delivered small interfering RNA (siRNA) to the brain's microglia immune cells to suppress the expression of a protein linked to excessive inflammation in Alzheimer's disease.