ONE microscopy: from molecule to 3D structure with conventional microscopy

Researchers at the University Medical Center Göttingen (UMG), Germany, have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy enables the detection of structural changes in damaged or toxic proteins in human samples. Diseases such as Parkinson's disease, which are based on protein misfolding, could thus be detected and treated at an early stage.