Advanced SAXS-MD framework reveals RNA nanoparticle dynamics in solution

Extensive work and advancements in blooming field of RNA nanotechnology continuously introduce new design and characterization principles for self-assembling nucleic acid nanoparticles (NANPs), enabling coordinated delivery and release of multiple therapeutic nucleic acids while modulating their immunorecognition. However, the rapid development of NANP technologies leads to increasingly complex structures, thus demanding new experimental pipelines for comprehensive and accurate structural characterization of both current and future designs.