Breakthrough in the precision engineering of four-stranded beta-sheets

A newly developed approach can precisely produce four-stranded β-sheets through metal–peptide coordination, report researchers from Institute of Science Tokyo. Their innovative methodology overcomes long-standing challenges in controlled β-sheet formation, including fibril aggregation and uncontrolled isomeric variation in the final product. This breakthrough could advance the study and application of β-sheets in biotechnology and nanotechnology.