Defining the immunological effects of nucleic acid nanoparticles

Programmable nucleic acid nanoparticle (NANP) technology is a relatively new field that has already given rise to a host of self-assembling nucleic acid nanoparticles that are increasingly viewed as promising biological materials for medical applications. Programmable self-assembling NANPs are amenable to chemical modifications, control over functionalization, and consistent batch-to-batch formulation. Researchers present the first detailed and systematic study that involved 25 most representative NANPs, originally designed by different groups, screened for the induction of 29 different cytokines.