New method gives microscope a boost in resolution: Mirrored slides now allow significantly sharper images
Date | 11th, Dec 2018 |
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Source | ScienceDaily - General News Websites |
DESCRIPTION
Scientists have been able to boost current super-resolution microscopy by a novel tweak. They coated the glass cover slip as part of the sample carrier with tailor-made biocompatible nanosheets that create a 'mirror effect'. This method shows that localizing single emitters in front of a metal-dielectric coating leads to higher precision, brightness and contrast in Single Molecule Localization Microscopy (SMLM).