Size matters: Color imaging of gene expression in electron microscopy

Researchers at Helmholtz Zentrum Muenchen have developed a method to visualize gene expression of cells with an electron microscope. Although electron microscopy currently provides the most detailed look into cells, it cannot differentiate which genetic programs run inside individual cells. The new method can now have a closer look by using genetically programmed nanospheres of different sizes as "multicolor" markers, which could even be helpful to investigate how memories are stored in neuronal networks.