Novel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency: Researchers used lipid nanoparticles to deliver CRISPR/Cas9 gene editing tools for potential treatment of hyperlipidemia.

Researchers have developed a significantly improved delivery mechanism for the CRISPR/Cas9 gene editing method in the liver. The delivery uses biodegradable synthetic lipid nanoparticles that carry the molecular editing tools into the cell to precisely alter the cells' genetic code with as much as 90 percent efficiency. The nanoparticles could help overcome technical hurdles to enable gene editing in a broad range of clinical therapeutic applications.