Multifunctional polymeric nanoparticles with trimodal affinity for liver cancer therapy

Hepatocellular carcinoma (HCC) is is the most common type of primary liver cancer and one of the most aggressive and hyper-vascularized forms of cancer. Many current chemotherapeutics fail to achieve the effective therapeutic index in the solid tumours due to poor drug penetration, poor bioavailability, non-specificity and drug resistance - a challenging aspect in this field. In search of new modalities, researchers have developed multifunctional polymeric nanoparticles against HCC. These biocompatible multifunctional polymeric nanoparticles hold trimodal affinity towards targeting microtubules, tyrosine kinases, and high-sensitivity imaging system quantum dots.