Nanomaterials based strategies for treatment of hypoxic tumor

Hypoxia is a typical characteristic of most tumors, owing to the fast consumption of oxygen by tumor tissue over the supply through malformed and abnormal tumor vasculature. Hypoxia in tumor tissue promotes the probability of tumor metastasis and endows hypoxia-tolerant tumor cells with resistance to some tumor therapies, including chemotherapy, radiotherapy, photodynamic therapy, and immunotherapy.