Protein corona determines fate and cytotoxicity of nanoparticles

The physicochemical properties of nanoparticles alone cannot predict the fate of nanoparticles in biological systems. Current evidence suggests that the formation of a corona on the nanoparticle surface is the most important parameter that controls nanoparticle toxicity. Scientists now showed that protein corona modulates internalisation and cytotoxicity of nanodiamonds in non-phagocytic and phagocytic cells. Specifically, they found that corona made of bovine serum albumin (BSA), which represents the most abundant protein in blood plasma, reduced nanodiamond agglomeration.