Characterization of the biomolecular corona at the single nanoparticle level

Scientists developed a new method to better understand how nanomedicines interact with patients' biomolecules. When nanoparticles enter human blood, they come into immediate contact with various biomolecules. These biomolecules form a coating layer on the nanoparticle surface - the so-called biomolecular corona - thereby imparting a unique biological identity to the nanoparticle, which could be very different from the pristine nanoparticle surface.