Highly efficient photodynamic-immunotherapy by combining AIEgen with Poly(I:C)

The study reports the design and preparation of erythrocyte membrane-bound nanoparticles (M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of aggregation-induced emission polymer (AIEgens) (named P2-PPh3) and polyinosinic : polycytidylic (Poly(I:C)), followed by erythrocyte membrane encapsulation. The M@AP nanoparticles combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I:C) to achieve synergistic activation of the immune system for anti-tumor activity.