Scientists identify G-Exos as a nanocarrier for miRNA transfer to stimulate neural differentiation of stem cells

Differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into functional neural cells is of tremendous significance to treat neural diseases. However, the limited neural differentiation of BMSCs remains a major challenge. Recent studies suggest that miRNAs may play a crucial role in regulating the neural differentiation of stem cells as effective signaling molecules. Due to their unique physiochemical attributes, miRNAs cannot be efficiently delivered in vitro and in vivo, thus inhibiting the application and translation of miRNAs.