Gold Nanoshells Enhance LDI-MS Tissue Imaging

Plasmonic nanoshells have been accepted as effective nanomaterials for LDI-MS recognition of many small molecules, although their uses in mass spectrometry imaging (MSI) are not much established. A study in the article ACS Applied Nano Materials reported the development and optimization of SiO2@Au nanoshells having custom shell compositions and structures for high-sensitivity LDI-MS analysis and a variety of MSI bases applications.