Identifying favorable immunological profiles suitable for personalized treatments with RNA nanoparticles

Therapeutic nucleic acids (TNAs) and nucleic acid nanoparticles (NANPs) are designed to enact specific intracellular responses beneficial for various biomedical applications. TNAs become especially attractive to researchers and clinicians since their functional versatility, programmability and modularity show great promise for treating disorders such as viral infections, cancers, and genetic disorders. Scientists explore how the immune responses to NANPs change with various factors such as dimensionality (3D vs. 2D), composition (DNA vs. RNA), and functionalization with TNAs.