Researchers combine pMINFLUX, graphene energy transfer and DNA-PAINT for a super-resolution microscopy method for rapid differentiation of molecular structures in 3D

A team of researchers, led by Ludwig-Maximilians-University (LMU) chemist Prof. Philip Tinnefeld, has combined 2D MINFLUX microscopy with a new method for axial resolution. This combination, which exploits the special properties of graphene, enables an axial precision of less than 3 angstroms. It was only a few years ago that a resolution limit in optical microscopy which seemed fundamental was broken, when researchers overcame the resolution limit of around 250 nanometers (winning the 2014 Nobel Prize in Chemistry for their efforts). Since then, the methods of microscopy have progressed rapidly.