Researchers devise genetically encoded DNA origami for targeted and precise gene therapy in vivo

As genetic information carriers, nucleic acid molecules have been developed as gene therapeutic drugs. On the basis of complementary base pairing, nucleic acid can not only encode functional genes, but also precisely self-assemble into nanostructures with specific sizes and shapes. However, the innate property (encoding gene) of these DNA nanostructures has rarely been displayed for gene therapy.