Nanotechnologies - Endotoxin test on nanomaterial samples for in vitro systems - Limulus amebocyte lysate (LAL) test

Nanotechnologies - Endotoxin test on nanomaterial samples for in vitro systems - Limulus amebocyte lysate (LAL) test

Standard Number NF EN ISO 29701 2011
Organization French national organization for standardization France
Level National
Category Test Method | Characterization | Measurement
Status
  • JAN 2011 Published
ABSTRACT
This document describes the application of an assay using the LAL (Limulus Amebocyte Lysate) reagent to evaluate nanomaterials for in vitro cell culture bioassay systems. The assay is suitable for use with samples of nanomaterials dispersed in an aqueous medium, e.g. water, physiological saline or reaction medium, as well as media incubated with nanomaterials for a given time at 37 ° C. It is designed for samples intended for in vitro systems, however, the methods can also be adapted for nanomaterials being administered to animals parenterally.