This Technical Specification provides methodology for the quantification of nano-object release from
powders as a result of treatment, ranging from handling to high energy dispersion, by measuring aerosols
liberated after a defined aerosolization procedure. In addition to information in terms of mass, the
aerosol is characterized for particle concentrations and size distributions. This Technical Specification
provides information on factors to be considered when selecting from the available methods for powder
sampling and treatment procedures and specifies minimum requirements for test sample preparation,
test protocol development, measuring particle release and reporting data. In order to characterize the
full size range of particles generated, the measurement of nano-objects as well as agglomerates and
aggregates is recommended in this Technical Specification.
This Technical Specification does not include the characterization of particle sizes within the powder.
Tribological methods are excluded where direct mechanical friction is applied to grind or abrade the material.
