Trapping Toxins to Prevent Sepsis

Date	14th, Jun 2023

Summary:

Researchers from Singapore have developed synthetic nanonets, which catch bacterial toxins and pro-inflammatory cytokine molecules, offering potential breakthroughs in sepsis treatment.

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June 14, 2023 Health,In the Lab By Parvaiz Yousuf Trapping Toxins to Prevent Sepsis Researchers from Singapore have developed synthetic nanonets, which catch bacterial toxins and pro-inflammatory cytokine molecules, offering potential breakthroughs in sepsis treatment. SHARE SHARE tweet share AsianScientist (Jun. 14, 2023) – Researchers in Singapore have created multifunctional synthetic peptide nanonets as targeted therapies for sepsis. These nanonets help reduce inflammation caused by bacterial infections by catching both bacterial endotoxins and pro-inflammatory cytokines. The study was published in Advanced Healthcare Materials. Sepsis is a life-threatening condition characterised by body’s extreme response to an infection. It happens when an already existing infection triggers a chain reaction throughout the body, most often in lungs, skin and gastrointestinal tract. Previously researchers have tried to develop targeted therapies against sepsis, but they have been largely unsuccessful. The researchers of this study focused on multi-cytokine techniques to come up with a new method of treating sepsis. Previously the team had prepared a design of antimicrobial peptides that self-assemble into nanonets capable of trapping bacteria. In this new study, they found that these peptide nanonets have additional functionalities that can reduce the inflammation typically seen in response to bacterial infections. The nanonets showed anti-inflammatory efficacy by binding and entrapping gram-negative pathogen-released endotoxins and inflammation mediators produced by host macrophages. Because of the net charge difference between pro-inflammatory and anti-inflammatory cytokines, the nanonets exhibited a good preference for binding the former while minimally interacting with the latter. In addition, the nanonets showed significant efficacy in reviving colistin’s (an antibiotic) antibacterial action against gram-negative infections, making it suitable for use as a last-resort treatment. This discovery is significant because it shows for the first time that multifunctional peptide nanonets can have far-reaching impacts in reducing sepsis complications at multiple stages. The peptide nanonets were able to lower the levels of pro-inflammatory cytokines that caused inflammation in the lungs of mice, which had been given endotoxins to damage their lungs. Moreover, the peptide nanonets were as effective as the drug dexamethasone, which is a steroidal drug used to relieve inflammation. “As a multifunctional biomaterial for the integrative treatment of sepsis, our peptide-based nanonets have demonstrated exceptional therapeutic potential. Our long-term goal is to further develop these tools for clinical application”, said Rachel EE, Associate Professor Department of Pharmacy at the National University of Singapore, in an article published by EurekAlert. She is the corresponding author of the study. This innovative research provides new options for addressing sepsis-related problems in healthcare. The selective trapping of endotoxins and pro-inflammatory cytokines by peptide nanonets is a major step forward. By simultaneously targeting the key components involved in the inflammatory response, these nanonets offer a more comprehensive approach to managing sepsis complications. As multifunctional anti-infective biomaterial, nanonets can be a promising option for restoring antibacterial efficacy against gram-negative pathogens. The implications of this study’s findings for the treatment of sepsis are enormous. The research team continues to improve the peptide nanonets for clinical application. The multifunctional capabilities of these nanonets provide a promising avenue for future research and development in the field of biomaterials and targeted therapies. Source: National University of Singapore ; Image: Adobe Stock The article can be found at: Multifunctional Antibacterial Nanonets Attenuate Inflammatory Responses through Selective Trapping of Endotoxins and Pro-Inflammatory Cytokines. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff. #Inflammation #Nanonets #Sepsis #Toxins Parvaiz Yousuf Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India. Parvaiz Yousuf Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India. Related Stories from Asian Scientist In the LabB Cells Found To Contribute To Sepsis B cells, better known for producing antibodies, have now been found to also play an important role in the inflammatory response against bacterial toxins during sepsis. In the LabNew Gene Involved In Sepsis Found A large-scale forward genetic screen has identified Gasdermin-D as a key mediator of the lethal septic shock response to bacteria. In the LabChinese Mung Bean Could Protect Against Sepsis, Study Researchers have discovered that a bean commonly used in Chinese cuisine may protect against sepsis, a life-threatening complication of an infection or injury. In the LabHow Bats Can Carry Viruses Without Getting Sick Scientists in Singapore have discovered that a subdued immune response may be the reason why bats can harbor deadly viruses without batting an eyelid. AcademiaTadamitsu Kishimoto Wins 2020 Tang Prize Tadamitsu Kishimoto of Osaka University is one of three recipients of the 2020 Tang Prize in Biopharmaceutical Sciences. PharmaBoehringer Ingelheim And Enleofen Bio Strike Billion-Dollar Deal Enleofen Bio will receive more than US$1 billion in earnout payments from Boehringer Ingelheim’s acquisition of worldwide exclusive rights to its preclinical interleukin-11 platform. EDITOR’S PICK Accelerating Decarbonization: Fugaku In The Race To Net Zero In a race against time, researchers are tapping into the computational power of Fugaku to solve our world’s pressing carbon problem. Human ‘Blood Microbiome’ Disproved In the most comprehensive study to date, Singaporean researchers have debunked the existence of a shared microbial community in healthy human blood. The breakthrough offers a vital baseline to prevent transfusion-related sepsis. Saving Tigers Helped Reduce India’s Carbon Emissions Research shows that tiger conservation interventions prevented forest loss, leading to reduced emissions and ecosystem benefits. Asian Scientist Magazine Copyright © 2011-2023 Wildtype Media Group PTE LTD. 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June 14, 2023 Health,In the Lab By Parvaiz Yousuf

Trapping Toxins to Prevent Sepsis Researchers from Singapore have developed synthetic nanonets, which catch bacterial toxins and pro-inflammatory cytokine molecules, offering potential breakthroughs in sepsis treatment.

Trapping Toxins to Prevent Sepsis

SHARE SHARE tweet share AsianScientist (Jun. 14, 2023) – Researchers in Singapore have created multifunctional synthetic peptide nanonets as targeted therapies for sepsis. These nanonets help reduce inflammation caused by bacterial infections by catching both bacterial endotoxins and pro-inflammatory cytokines. The study was published in Advanced Healthcare Materials. Sepsis is a life-threatening condition characterised by body’s extreme response to an infection. It happens when an already existing infection triggers a chain reaction throughout the body, most often in lungs, skin and gastrointestinal tract. Previously researchers have tried to develop targeted therapies against sepsis, but they have been largely unsuccessful. The researchers of this study focused on multi-cytokine techniques to come up with a new method of treating sepsis. Previously the team had prepared a design of antimicrobial peptides that self-assemble into nanonets capable of trapping bacteria. In this new study, they found that these peptide nanonets have additional functionalities that can reduce the inflammation typically seen in response to bacterial infections. The nanonets showed anti-inflammatory efficacy by binding and entrapping gram-negative pathogen-released endotoxins and inflammation mediators produced by host macrophages. Because of the net charge difference between pro-inflammatory and anti-inflammatory cytokines, the nanonets exhibited a good preference for binding the former while minimally interacting with the latter. In addition, the nanonets showed significant efficacy in reviving colistin’s (an antibiotic) antibacterial action against gram-negative infections, making it suitable for use as a last-resort treatment. This discovery is significant because it shows for the first time that multifunctional peptide nanonets can have far-reaching impacts in reducing sepsis complications at multiple stages. The peptide nanonets were able to lower the levels of pro-inflammatory cytokines that caused inflammation in the lungs of mice, which had been given endotoxins to damage their lungs. Moreover, the peptide nanonets were as effective as the drug dexamethasone, which is a steroidal drug used to relieve inflammation. “As a multifunctional biomaterial for the integrative treatment of sepsis, our peptide-based nanonets have demonstrated exceptional therapeutic potential. Our long-term goal is to further develop these tools for clinical application”, said Rachel EE, Associate Professor Department of Pharmacy at the National University of Singapore, in an article published by EurekAlert. She is the corresponding author of the study. This innovative research provides new options for addressing sepsis-related problems in healthcare. The selective trapping of endotoxins and pro-inflammatory cytokines by peptide nanonets is a major step forward. By simultaneously targeting the key components involved in the inflammatory response, these nanonets offer a more comprehensive approach to managing sepsis complications. As multifunctional anti-infective biomaterial, nanonets can be a promising option for restoring antibacterial efficacy against gram-negative pathogens. The implications of this study’s findings for the treatment of sepsis are enormous. The research team continues to improve the peptide nanonets for clinical application. The multifunctional capabilities of these nanonets provide a promising avenue for future research and development in the field of biomaterials and targeted therapies. Source: National University of Singapore ; Image: Adobe Stock The article can be found at: Multifunctional Antibacterial Nanonets Attenuate Inflammatory Responses through Selective Trapping of Endotoxins and Pro-Inflammatory Cytokines. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff. #Inflammation #Nanonets #Sepsis #Toxins Parvaiz Yousuf Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India. Parvaiz Yousuf Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India.

SHARE SHARE tweet share

AsianScientist (Jun. 14, 2023) – Researchers in Singapore have created multifunctional synthetic peptide nanonets as targeted therapies for sepsis. These nanonets help reduce inflammation caused by bacterial infections by catching both bacterial endotoxins and pro-inflammatory cytokines. The study was published in Advanced Healthcare Materials. Sepsis is a life-threatening condition characterised by body’s extreme response to an infection. It happens when an already existing infection triggers a chain reaction throughout the body, most often in lungs, skin and gastrointestinal tract. Previously researchers have tried to develop targeted therapies against sepsis, but they have been largely unsuccessful. The researchers of this study focused on multi-cytokine techniques to come up with a new method of treating sepsis. Previously the team had prepared a design of antimicrobial peptides that self-assemble into nanonets capable of trapping bacteria. In this new study, they found that these peptide nanonets have additional functionalities that can reduce the inflammation typically seen in response to bacterial infections. The nanonets showed anti-inflammatory efficacy by binding and entrapping gram-negative pathogen-released endotoxins and inflammation mediators produced by host macrophages. Because of the net charge difference between pro-inflammatory and anti-inflammatory cytokines, the nanonets exhibited a good preference for binding the former while minimally interacting with the latter. In addition, the nanonets showed significant efficacy in reviving colistin’s (an antibiotic) antibacterial action against gram-negative infections, making it suitable for use as a last-resort treatment. This discovery is significant because it shows for the first time that multifunctional peptide nanonets can have far-reaching impacts in reducing sepsis complications at multiple stages. The peptide nanonets were able to lower the levels of pro-inflammatory cytokines that caused inflammation in the lungs of mice, which had been given endotoxins to damage their lungs. Moreover, the peptide nanonets were as effective as the drug dexamethasone, which is a steroidal drug used to relieve inflammation. “As a multifunctional biomaterial for the integrative treatment of sepsis, our peptide-based nanonets have demonstrated exceptional therapeutic potential. Our long-term goal is to further develop these tools for clinical application”, said Rachel EE, Associate Professor Department of Pharmacy at the National University of Singapore, in an article published by EurekAlert. She is the corresponding author of the study. This innovative research provides new options for addressing sepsis-related problems in healthcare. The selective trapping of endotoxins and pro-inflammatory cytokines by peptide nanonets is a major step forward. By simultaneously targeting the key components involved in the inflammatory response, these nanonets offer a more comprehensive approach to managing sepsis complications. As multifunctional anti-infective biomaterial, nanonets can be a promising option for restoring antibacterial efficacy against gram-negative pathogens. The implications of this study’s findings for the treatment of sepsis are enormous. The research team continues to improve the peptide nanonets for clinical application. The multifunctional capabilities of these nanonets provide a promising avenue for future research and development in the field of biomaterials and targeted therapies. Source: National University of Singapore ; Image: Adobe Stock The article can be found at: Multifunctional Antibacterial Nanonets Attenuate Inflammatory Responses through Selective Trapping of Endotoxins and Pro-Inflammatory Cytokines. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff. #Inflammation #Nanonets #Sepsis #Toxins Parvaiz Yousuf Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India. Parvaiz Yousuf Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India.

#Inflammation #Nanonets #Sepsis #Toxins

Parvaiz Yousuf Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India.

Parvaiz Yousuf

Parvaiz Yousuf is a science journalist and researcher based in Kashmir, India.

Related Stories from Asian Scientist In the LabB Cells Found To Contribute To Sepsis B cells, better known for producing antibodies, have now been found to also play an important role in the inflammatory response against bacterial toxins during sepsis. In the LabNew Gene Involved In Sepsis Found A large-scale forward genetic screen has identified Gasdermin-D as a key mediator of the lethal septic shock response to bacteria. In the LabChinese Mung Bean Could Protect Against Sepsis, Study Researchers have discovered that a bean commonly used in Chinese cuisine may protect against sepsis, a life-threatening complication of an infection or injury. In the LabHow Bats Can Carry Viruses Without Getting Sick Scientists in Singapore have discovered that a subdued immune response may be the reason why bats can harbor deadly viruses without batting an eyelid. AcademiaTadamitsu Kishimoto Wins 2020 Tang Prize Tadamitsu Kishimoto of Osaka University is one of three recipients of the 2020 Tang Prize in Biopharmaceutical Sciences. PharmaBoehringer Ingelheim And Enleofen Bio Strike Billion-Dollar Deal Enleofen Bio will receive more than US$1 billion in earnout payments from Boehringer Ingelheim’s acquisition of worldwide exclusive rights to its preclinical interleukin-11 platform.

In the Lab

Academia

Pharma

EDITOR’S PICK Accelerating Decarbonization: Fugaku In The Race To Net Zero In a race against time, researchers are tapping into the computational power of Fugaku to solve our world’s pressing carbon problem. Human ‘Blood Microbiome’ Disproved In the most comprehensive study to date, Singaporean researchers have debunked the existence of a shared microbial community in healthy human blood. The breakthrough offers a vital baseline to prevent transfusion-related sepsis. Saving Tigers Helped Reduce India’s Carbon Emissions Research shows that tiger conservation interventions prevented forest loss, leading to reduced emissions and ecosystem benefits.

EDITOR’S PICK

Accelerating Decarbonization: Fugaku In The Race To Net Zero In a race against time, researchers are tapping into the computational power of Fugaku to solve our world’s pressing carbon problem. Human ‘Blood Microbiome’ Disproved In the most comprehensive study to date, Singaporean researchers have debunked the existence of a shared microbial community in healthy human blood. The breakthrough offers a vital baseline to prevent transfusion-related sepsis. Saving Tigers Helped Reduce India’s Carbon Emissions Research shows that tiger conservation interventions prevented forest loss, leading to reduced emissions and ecosystem benefits.

Accelerating Decarbonization: Fugaku In The Race To Net Zero In a race against time, researchers are tapping into the computational power of Fugaku to solve our world’s pressing carbon problem.

In a race against time, researchers are tapping into the computational power of Fugaku to solve our world’s pressing carbon problem.

Human ‘Blood Microbiome’ Disproved In the most comprehensive study to date, Singaporean researchers have debunked the existence of a shared microbial community in healthy human blood. The breakthrough offers a vital baseline to prevent transfusion-related sepsis.

In the most comprehensive study to date, Singaporean researchers have debunked the existence of a shared microbial community in healthy human blood. The breakthrough offers a vital baseline to prevent transfusion-related sepsis.

Saving Tigers Helped Reduce India’s Carbon Emissions Research shows that tiger conservation interventions prevented forest loss, leading to reduced emissions and ecosystem benefits.

Research shows that tiger conservation interventions prevented forest loss, leading to reduced emissions and ecosystem benefits.

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Trapping Toxins to Prevent Sepsis

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