Cancer has a high death rate with delayed diagnosis of the disease being one of the main reasons for its fatality. Early diagnosis of cancer is vital to improving patient outcomes and in recent years, the development of diagnostic tools to detect early-stage cancer has gained a lot of attention. Cancer cells utilize specific micro-ribonucleic acids (miRNAs)-small noncoding RNAs to regulate gene expression and promote tumor formation. While circulating miRNAs are viable biomarkers of early cancer disease, the identification of cancer-related miRNAs in blood and other body fluids remains a challenge.