Date | 17th, Dec 2018 |
---|
Home > Press > Vitamin E TPGS emulsified vinorelbine bitartrate loaded solid lipid nanoparticles (SLN): This article by Dr. Sanjay Singh et al. is published in Current Drug Delivery, Volume 15 , Issue 8 , 2018
Abstract: Vinorelbine Bitartrate (VRL), a semi-synthetic vinca alkaloid was approved by the FDA for breast cancer treatment, as it has been proven to be beneficial for first line of defense and subsequent therapies. But its hydrophilic and thermolabile structure causes hindrance to oral clinical translation. The main objective of this research is the development and optimization of a solid lipid nanoparticle (SLN) structure that can encapsulate hydrophilic and thermolabile Vinorelbine bitartrate to maximize the anticancer activity of the drug without compromising its efficacy and integrity. For this purpose, the study is mainly focused on the application of DOE, a modern statistical optimization tool for nanoparticle modification.
Sharjah, U.A.E. | Posted on December 14th, 2018
To prepare SLNs, a solvent diffusion technique was used employing Taguchi orthogonal array design with process variables and optimized formulation. Glyceryl mono-oleate (GMO) were used for its emulsifying nature and low melting point to enhance entrapment and reducing temperature associated degradation. To prevent infection, two types of surfactants, Vitamin E TPGS, and Poloxamer-188 were used to obtain TPGS-VRL-SLNs and PL-VRL-SLNs.
The results proved the method to be effective. The SLNs were produced spherical in shape with entrapment efficiency (EE) upto 58%. A biphasic release pattern was observed in in vitro release studies followed by the Korsemeyer peppas model with fickian release kinetics. MTT assay results revealed that TPGS-VRL-SLNs and PL-VRL-SLNs were 39.5 and 18.5 time more effective than VRL in its original nature. The DOE method was believed to be a successful approach for development of VRL-SLNs. Enhanced entrapment with anticancer efficacy of TPGS-VRL-SLN was the result of emulsifying nature of GMO and the cytotoxic nature of TPGS which influences VRL effects. Such properties of TPGS-VRL-SLNs may prove them to be a potentially useful carrier in cancer chemotherapeutics.
####
For more information, please click here
Contacts:Faizan ul Haq
Copyright © Bentham Science Publishers
If you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
News and information
Scientists unravel 'Hall effect' mystery in search for next generation memory storage devices August 19th, 2022
Researchers design new inks for 3D-printable wearable bioelectronics: Potential uses include printing electronic tattoos for medical tracking applications August 19th, 2022
Cancer
New technology helps reveal inner workings of human genome June 24th, 2022
New nano-gel to protect children receiving chemotherapy from hearing loss June 17th, 2022
Electron-phonon coupling assisted universal red luminescence of o-phenylenediamine-based CDs June 10th, 2022
Possible Futures
New chip ramps up AI computing efficiency August 19th, 2022
Rice team eyes cells for sophisticated data storage: National Science Foundation backs effort to turn living cells into equivalent of computer RAM August 19th, 2022
Nanomedicine
Discoveries
Scientists unravel 'Hall effect' mystery in search for next generation memory storage devices August 19th, 2022
Researchers design new inks for 3D-printable wearable bioelectronics: Potential uses include printing electronic tattoos for medical tracking applications August 19th, 2022
Visualizing nanoscale structures in real time: Open-source software enables researchers to see materials in 3D while they're still on the electron microscope August 19th, 2022
Announcements
Scientists unravel 'Hall effect' mystery in search for next generation memory storage devices August 19th, 2022
Researchers design new inks for 3D-printable wearable bioelectronics: Potential uses include printing electronic tattoos for medical tracking applications August 19th, 2022
Visualizing nanoscale structures in real time: Open-source software enables researchers to see materials in 3D while they're still on the electron microscope August 19th, 2022
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
Scientists unravel 'Hall effect' mystery in search for next generation memory storage devices August 19th, 2022
Researchers design new inks for 3D-printable wearable bioelectronics: Potential uses include printing electronic tattoos for medical tracking applications August 19th, 2022
Visualizing nanoscale structures in real time: Open-source software enables researchers to see materials in 3D while they're still on the electron microscope August 19th, 2022
Nanobiotechnology
Rice team eyes cells for sophisticated data storage: National Science Foundation backs effort to turn living cells into equivalent of computer RAM August 19th, 2022