Experiments in mice and human cells shed light on best way to deliver nanoparticle therapy for cancer

Date26th, Mar 2020

Summary:

Researchers in the cancer nanomedicine community debate whether use of tiny structures, called nanoparticles, can best deliver drug therapy to tumors passively -- allowing the nanoparticles to diffuse into tumors and become held in place, or actively -- adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice by investigators at the Johns Hopkins Kimmel Cancer Center suggests the question is even more complicated.

Full text:

HER2+ Tumor

image: Histology image of HER2+ tumor showing accumulation of Herceptin-labeled nanoparticle (upper right, and blue in histology) accumulation in tumor microenvironment (immune) and not on HER2+ cancer cells. view more 

Credit: Robert Ivkov, Ph.D.

Researchers in the cancer nanomedicine community debate whether use of tiny structures, called nanoparticles, can best deliver drug therapy to tumors passively -- allowing the nanoparticles to diffuse into tumors and become held in place, or actively -- adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice by investigators at the

Source:

EurekAlert