Fatty acid in triglycerides proves an effective platform for biological drug delivery

Date1st, Apr 2020

Summary:

Houston Methodist nanomedicine researchers are studying a new drug delivery system that transports oral medication via triglycerides that could eliminate the need for injections or IV treatments of some biologic drugs for rheumatoid arthritis and other autoimmune diseases. They're doing this with a diabetes drug that resulted in approximately 25% absorption in mice models, considered very high for an oral drug. The research will appear in Science Advances April 1.

Full text:

Insulin Production in Diabetic Pancreatic Tissue Cells

image: Houston Methodist researchers designed a platform where a diabetes drug was chemically linked to fatty acids and then packaged in a nanoparticle resistant to the stomach's gastric acids. Once inside the small intestine, the drug molecules were released from the nanoparticle and 24.8% of the drug was absorbed. view more 

Credit: Haifa Shen, Houston Methodist

HOUSTON-(April 1, 2020)-We've all been warned about the dangers of triglycerides, the fat stored in your blood. But what if that unhealthy fat could effectively transport oral medication to your body and eliminate the need for some injections or IV treatment?

Source:

EurekAlert