Nanotechnology Now - Press Release: Nanothermometry to improve anticancer strategies

Date	11th, Feb 2021

Summary:

In hyperthermia treatments, the temperature is raised above physiological levels to induce the death of cancerous cells. The *local application of hyperthermia is key for a successful treatment* and...

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Photothermal excitation of gold-based nanomaterials: the nanoparticle absorbs NIR (near infrared) light resulting in a localized heating. X-rays act as a probe of the local temperature. Image credit: NanoLetteres

Abstract: In hyperthermia treatments, the temperature is raised abovephysiological levels to induce the death of cancerous cells. The *localapplication of hyperthermia is key for a successful treatment* and toreduce damage to the healthy surrounding tissues. Going down to thenanoscale, nanoparticles can be used in hyperthermia treatments actingas nanoheaters and triggering cellular damage and/or inducing drugrelease in a selective manner.

Madrid, Spain | Posted on February 10th, 2021

The optimization of the heat capability of the nanoparticles is veryimportant to better adjust the therapeutic thermal onset, since, in somecases, thermal healing effects may occurs though local heating without amacroscopic temperature rise. Measuring the nanoscale details of theheating in the surrounding of the nanoparticles is challenging; so farindirect methods have been tested.

In their /Nano Letters /publication, a group of researchers led by Dr.Ana Espinosa (IMDEA Nanociencia) and �lvaro Mu�oz-Noval (UCM) haveproposed the measurement of the nanoscale heating of gold-basednanoparticles under hyperthermia conditions using X-ray absorptionspectroscopy as an onsite and direct nanothermometric method. Theresults reveal *significant nanothermal gradients*, it is, hightemperature variations within a small volume and evidence a nanoscopiclocal temperature significantly higher than global temperaturemeasurements. This method is versatile and allows to measure the heatingat the nanoscale for all types of particles and systems underhyperthermia exposure.

This work is an outcome of Dr. Ana Espinosa�s research group at IMDEANanociencia and has been partially funded by the �Atracci�n deTalento�//Grant from Comunidad de Madrid, the Spanish AssociationAgainst Cancer (AECC), and the Severo Ochoa Excellence award to IMDEANanociencia (2017-2021).

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Contacts:IMDEA NanocienciaC/Faraday 928049 Madrid, SpainTel.: +34 91 299 87 00www.nanociencia.imdea.orgTwitter: @IMDEA_NanoFacebook: @IMDEANanocienciaInstagram: @IMDEANanociencia

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