Date31st, May 2019

Summary:

Nanomaterials have unique physical and chemical features. OECD's Decision Framework and Guiding Principles tools fill data gaps in the hazard characterisation by identifying the most useful parameters and best available methods for a given type of nanomaterial.

Full text:

The purpose of the OECD Series on the Safety of Manufactured Nanomaterials is to provide up-to-date information on the OECD activities related to human health and environmental safety.

WHAT's new

Physico-chemical properties for nanomaterials can differ from those commonly considered for non-nanomaterials challenging their risk assessment. The OECD developed tools to identify which test methods are (or are not) appropriate to measure a given physico-chemical parameter considered key to characterization and identification, for a given type of nanomaterial. Together, the Physical-Chemical Decision Framework to inform Decisions for Risk Assessment of Manufactured Nanomaterials and its Guiding Principles are collectively intended to facilitate the identification of the most useful parameters and best available methods while maintaining rigour in data quality and reporting. Together they offer an approach to gather fit-for-purpose physico-chemical information to more fully understand the behaviour of nanomaterials in biotic and abiotic systems.

2022 REPORTS

No. 103 - Important Issues on Risk Assessment of Manufactured Nanomaterials

2021 REPORTS

No. 102 - Developments in Delegations on the Safety of Manufactured Nanomaterials – Tour de Table No. 101- Evaluation of Tools and Models for Assessing Occupational and Consumer Exposure to Manufactured Nanomaterials; Part III: Performance testing results of tools/models for consumer exposure No. 100 - Evaluation of Tools and Models for Assessing Occupational and Consumer Exposure to Manufactured Nanomaterials; Part II: Performance testing results of tools/models for occupational exposure (Annex 1) No. 99 - Evaluation of Tools and Models for Assessing Occupational and Consumer Exposure to Manufactured Nanomaterials; Part I: Compilation of tools/models and analysis for further evaluation No. 98 - Evaluation of Tools and Models Used for Assessing Environmental Exposure to Manufactured Nanomaterials; Functional Assessment and Statistical Analysis of Nano-Specific Environmental Exposure Tools and Models; Annex 1

2020 REPORTS

No. 97 - Developments in Delegations on the Safety of Manufactured Nanomaterials – Tour de Table No. 96 - Moving Towards a Safe(r) Innovation Approach (SIA) for More Sustainable Nanomaterials and Nano-enabled Products No. 95 - Advancing Adverse Outcome Pathway (AOP) Development for Nanomaterial Risk Assessment and Categorisation/ PART3: Workshop Report and Recommendations No. 94 - Advancing Adverse Outcome Pathway (AOP) Development for Nanomaterial Risk Assessment and Categorisation/ PART2: Case Study on Tissue Injury No. 93 - Advancing Adverse Outcome Pathway (AOP) Development for Nanomaterial Risk Assessment and Categorisation/ PART1: Final Project Report and Recommendations with Methodology to Prioritise Key Events (KEs) Relevant for Manufactured Nanomaterials No. 92 - Ability of biopersistent/biodurable manufactured nanomaterials (MNs) to induce lysosomal membrane permeabilization (LMP) as a prediction of their long-term toxic effects

2019 REPORTS

No. 91 - Guiding Principles for Measurements and Reporting for Nanomaterials: Physical Chemical Parameters No. 90 - Physical-Chemical Decision Framework to inform Decisions for Risk Assessment of Manufactured Nanomaterials (see accompanying worksheets) No. 89 - Developments in Delegations on the Safety of Manufactured Nanomaterials - Tour de Table

2018 REPORTS

No. 88 - Investigating the Different Types of Risk Assessments of Manufactured Nanomaterials No. 87 - Developments in Delegations on the Safety of Manufactured Nanomaterials - Tour de Table No. 86 - Assessment of Biodurability of Nanomaterials and the Surface Ligands No. 85 - Evaluation of in vitro methods for human hazard assessment applied in the OECD Testing Programme for the Safety of Manufactured Nanomaterials Test Guideline 318: Dispersion Stability of Nanomaterials in Simulated Environmental Media - Spreadsheet to be used in conjunction with TG 318 (Excel) Test Guideline 412: 28 days (Subacute) Inhalation Toxicity Study Test Guideline 413: 90 days (Subchronic) Inhalation Toxicity Study

2017 REPORTS

No. 84 - Consumer and Environmental Exposure to Manufactured Nanomaterials -Information Used to Characterize Exposures: Analysis of a Survey No. 83 - Silver Nanoparticles: Summary of the Dossier No. 82 - Strategies, Techniques and Sampling Protocols for Determining the Concentrations of Manufactured Nanomaterials in Air at the Workplace No. 81 - Developments in Delegations on the safety of manufactured nanomaterials (March 2017 - August 2017)  No. 80 - Alternative testing strategies in risk assessment of manufactured nanomaterials: current state of knowledge and research needs to advance their use

2016 REPORTS

No. 79 - Strategy for Using Metal Impurities as Carbon Nanotube Tracers No. 78 - Developments on the Safety of Manufactured Nanomaterials Tour de Table from OECD Delegations (Nov. 2015- Oct 2016) No. 77 - Gold Nanoparticle Occupational Exposure Assessment in A Pilot Scale Facility No. 76/ADD - Grouping and Read-Across for the Hazard Assessment of Manufactured Nanomaterials: Participants List to the Expert Meeting No. 76 - Grouping and Read-Across for the Hazard Assessment of Manufactured Nanomaterials No. 75 - Future Challenges Related to the Safety of Manufactured Nanomaterials: Report from the Special Session No. 74 - Exposure Assessment of Nano-Silver (AgNP):Case Study No. 73 - Titanium Dioxide: Summary of the Dossier No. 72 - Toxicokinetics of Manufactured Nanomaterials: Report from the OECD Expert Meeting (2016) No. 71 - Silicon dioxide: summary of the dossier No. 70 - Single walled carbon nanotubes (SWCNTs): summary of the dossier No. 69 - Fullerenes (C60): summary of the dossier No. 68 - Multiwalled carbon nanotubes (MWCNT): summary of the dossier No. 67 - Developments in delegations on the safety of manufactured nanomaterials - Tour de table No. 66 - Categorisation of manufactured nanomaterials  No. 65 - Physical-chemical properties of nanomaterials: Evaluation of methods applied in the OECD-WPMN testing programme  No. 64 - Approaches on nano grouping/ equivalence/ read-across concepts based on physical-chemical properties (GERA-PC) for regulatory regimes  No. 63 - Physical-chemical parameters: measurements and methods relevant for the regulation of nanomaterials 

2015-2006 REPORTS

No. 62 - Considerations for using dissolution as a function of surface chemistry to evaluate environmental behaviour of nanomaterials in risk assessments: Preliminary Case Study Using Silver Nanoparticles  No. 61 - Developments in delegations on the safety of manufactured nanomaterials - Tour de tablezzz  No. 60 - Developments in delegations on the safety of manufactured nanomaterials - Tour de table  No. 59 - Developments on the Safety of Manufactured Nanomaterials: 2013  No. 58 - Preliminary guidance notes on Nanomaterials: Interspecies variability factors in human health risk assessment  No. 57 - Guidance Manual towards the Integration of Risk Assessment into Life Cycle Assessment of Nano-Enabled Applications  No. 56 - Analysis of the Survey on Available Methods and Models for Assessing Exposure to Manufactured Nanomaterials  No. 55 - Harmonized Tiered Approach to Measure and Assess the Potential Exposure to Airborne Emissions of Engineered Nano-Objects and their Agglomerates and Aggregates at Workplaces  Nos. 44-54 - Dossiers derived from the Testing Programme on Manufactured Nanomaterials available at: http://www.oecd.org/chemicalsafety/nanosafety/testing-programme-manufactured-nanomaterials.htm No. 43 -  Genotoxicity of Manufactured Nanomaterials : Report of the OECD expert meeting  No. 42 -  Report of the questionnaire on regulatory regimes for manufactured nanomaterials 2010-2011  No. 41 - Report of the OECD expert meeting on the physical chemical properties of manufactured nanomaterials and test guidelines + Addendum  No. 40 - Ecotoxicology and Environmental Fate of Manufactured Nanomaterials: Test Guidelines + Addendum No. 39 - Workshop on Environmentally Sustainable Use of Manufactured Nanomaterials, September 2011, Rome, Italy  No. 38 - Co-Operation on Risk Assessment: Prioritisation of Important Issues on Risk Assessment of Manufactured Nanomaterials - Final Report  No. 37 - Developments on the Safety of Manufactured Nanomaterials - Tour de Table - 10th Meeting of the Working Party on Manufactured Nanomaterials   No. 36 - Guidance on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials  No. 35 - Inhalation Toxicity Testing: Expert Meeting on Potential Revisions to OECD Test Guidelines and Guidance Document  No. 34 - Developments on the Safety of Manufactured Nanomaterials - Tour de Table - 9th Meeting of the Working Party on Manufactured Nanomaterials  No. 33 - Important Issues on Risk Assessment of Manufactured Nanomaterials  No. 32 - National Activities on Life Cycle Assessment of Nanomaterials  No. 31 - Information Gathering Schemes on Nanomaterials: Lessons Learned and Reported Information  No. 30 - Regulated Nanomaterials: 2006-2009  No. 29 - Developments/Activities on the Safety of Manufactured Nanomaterials - Tour de Table - 8th Meeting of the Working Party on Manufactured Nanomaterials - ENV/JM/MONO(2011)12 No. 28 - Compilation and Comparison of Guidelines Related to Exposure to Nanomaterials in Laboratories - ENV/JM/MONO(2010)47 No. 27 - List of Manufactured Nanomaterials and List of Endpoints for Phase One of the Sponsorship Programme for the Testing of Manufactured Nanomaterials: Revision  No. 26 - Developments/Activities on the Safety of Manufactured Nanomaterials, Tour de Table - 7th Meeting of the Working Party on Manufactured Nanomaterials  No. 25 - Guidance Manual for the Testing of Manufactured Nanomaterials: OECD Sponsorship Programme: First Revision  No. 24 - Preliminary Guidance Notes on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials  No. 23 - Report of the Questionnaire on Regulatory Regimes for Manufactured Nanomaterials (2010)  No. 22 - OECD Programme on the Safety of Manufactured Nanomaterials 2009-2012 Operational Plans of the Projects   No. 21 - Report of the Workshop on Risk Assessment of Manufactured Nanomaterials in a regulatory context, September 2009, Washington D.C., USA  No. 20 - Developments/Activities on the Safety of Manufactured Nanomaterials: Tour de Table - 6th Meeting of the Working Party on Manufactured Nanomaterials, October 2009  No. 19 - Analysis of Information Gathering Initiatives on Manufactured Nanomaterials  No. 18 - Manufactured Nanomaterials: Roadmap for Activities during 2009 and 2010  No. 17 - Developments in Delegations and other International Organisations on the Safety of Manufactured Nanomaterials - Tour de Table  No. 16 - Manufactured Nanomaterials: Work Programme 2009- 2012  No. 15 - Preliminary Review of OECD Test Guidelines for their Applicability to Manufactured Nanomaterials  No. 14 - Guidance Manual for the Testing of Manufactured Nanomaterials: OECD's Sponsorship Programme  (This document has been updated)  No. 13 - Report of an OECD Workshop on Exposure Assessment and Exposure Mitigation: Manufactured Nanomaterials  No. 12 - Comparison of Guidance on Selection of Skin Protective Equipment and Respirators for Use in the Workplace: Manufactured Nanomaterials  No. 11 - Emission Assessment for Identification of Sources and Release of Airborne Manufactured Nanomaterials in the Workplace: Compilation of Existing Guidance  No. 10 - Identification, Compilation and Analysis of Guidance Information for Exposure Measurement and Exposure Mitigation: Manufactured Nanomaterials  No. 10 - Identification, compilation et analyse de documents d’orientation pour la mesure de l’exposition et la limitation de l’exposition : les nanomatériaux manufacturés  No. 9 - EHS Research Strategies on Manufactured Nanomaterials: Compilation of Outputs  No. 8 - Preliminary Analysis of Exposure Measurement and Exposure Mitigation in Occupational Settings: Manufactured Nanomaterials  No. 7 - Developments/Activities on the Safety of Manufactured Nanomaterials - Tour de Table - 4th Meeting of the Working Party on Manufactured Nanomaterials, June           2008  No. 6 - List of Manufactured Nanomaterials and List of Endpoints for Phase One of the OECD Testing Programme  No. 5 - Developments/Activities on the Safety of Manufactured Nanomaterials: Tour de Table - 3rd Meeting of the Working Party on Manufactured Nanomaterials, November 2007  No. 4 - Manufactured Nanomaterials: Programme of Work 2006-2008  No. 3 - Developments/Activities on the Safety of Manufactured Nanomaterials: Tour de table - 2nd Meeting of the Working Party on Manufactured Nanomaterials, April 2007  No. 2 - Developments/Activities on the Safety of Manufactured Nanomaterials: Tour de table - 1st Meeting of the Working Party on Manufactured Nanomaterials, October 2006  No. 1 - Report of the OECD Workshop on the Safety of Manufactured Nanomaterials: Building Co-operation, Co-ordination and Communication, December 2005 

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Testing Programme of Manufactured Nanomaterials

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