In Vitro Induction of Leukoc yte Procoagulant Activity by Nanoparticles

In Vitro Induction of Leukoc yte Procoagulant Activity by Nanoparticles

Standard Number ITA-17
Organization Nanotechnology Characterization Laboratory USA
Level National
Category Specification
Status
  • JAN 2011 Published
ABSTRACT
Leukocyte procoagulant activity (PCA) is accepted as an important component in the onset of disseminated intravascular coagulation (DIC). DIC is common in acute promyelocytic leukemia (APL) and other forms of cancer 1-5. DIC in cancer patients is often observed afterinitiation of therapy with cytotoxic oncology drugs that act by altering DNA replication (e.g.,doxorubicin, daunorubicin, and vincristin)3, 6.