Lysosomal dysfunction is recognized as a potential toxic mechanism for xenobiotics that can result in various pathological states(1). There is concern that nanopaticles, in particular, maycause lysosomal pathologies,since they are likely to accumulate within lysosomes (2). Lysosomal dysfunction could potentially result from biopersistance, or inhibition oflysosomal enzymes, such as inhibition of phospholipase resulting in phospholipidosis, or inhibition of lysosomal protein degradation resulting in lysosomal overload.
